Figure 7. Activated pDC infusions delay leukemia onset in humanized mice.

A. Experimental design. Irradiated newborn NSG mice were transplanted with 10⁴ human cord blood-derived CD34⁺ cells. 10⁵ REH ALL cells were intravenously injected in humanized mice 5-6 weeks after transplantation, followed by four weekly injections of activated pDCs or saline solution for control mice (CTL). B. Survival curves of ALL-bearing humanized mice treated with activated pDCs or saline solution injections. Mice were sacrificed after overt leukemia onset. Flow cytometry analysis of bone marrow samples confirmed complete leukemia involvement. Log-rank test was used to compare survival.