Table 2. SiRNA-induced drug sensitization in vitro.
| Drug | Cell line | Ercc1 | Ercc2 | Mutyh | Pnkp |
|---|---|---|---|---|---|
| CDDP | U373 | 19.9** | 15.8** | 16.9** | 17.6 ** |
| GHD | 24.9** | 10.1* | 10.8* | 12.1* | |
| LN229 | 24.7** | 16.9** | n.s. | n.s. | |
| U318 | 14.1** | n.s | n.s. | n.s. | |
| TMZ | U373 | 24.5** | 17.6** | 26.0** | 25.1** |
| GHD | 9.5** | n.s | n.s. | n.s. |
Drug sensitization index (DS) was measured for the 4 siRNA candidates on 6 cell lines (U373, U87, GHD, LN229, U138 and CCF). Data are the mean of 3 independent experiments. Only significant values are indicated. n.s., non-significant.