Figure 3. RPS3 knockdown prompted Ca²⁺ flooding into the mitochondrial.

A375 cells were treated with siRNA of RPS3 (50 nM) for 72 hr. The opening of permeability transition pore A. and the membrane potential of mitochondrial depolarization B. were determined. The translocation of mitochondrial into the ER C. and the flooding of calcium ions flooding into the mitochondrial D. were also analyzed by confocus microscope.