Table 1. The list of highly up-regulated and down-regulated genes with a neuronal function detected in human control pancreas and pancreas with type 2 diabetes (T2D) using mRNA expression.
| Protein ID | Protein description | pI | Mw (Da) | Gene name | Pan-T2D vs Pan-Cont (fold change) |
|---|---|---|---|---|---|
| Q8TAK6 | Oligodendrocyte transcription factor 1 | 9.71 | 27,905 | OLIG1 | 38.0 |
| O95817 | BAG family molecular chaperone regulator 3 | 6.46 | 61,595 | BAG3 | 34.2 |
| Q9UKW4 | Guanine nucleotide exchange factor VAV3 | 6.64 | 97,776 | VAV3 | −246.8 |
| P32239 | Gastrin/cholecystokinin type B receptor | 10.03 | 48,419 | CCKBR | −89.7 |
| Q9HAZ2 | PR domain zinc finger protein 16 | 5.81 | 140,251 | PRDM16 | −81,5 |
| P02647 | Apolipoprotein A1 | 5.56 | 30,778 | APOA1 | −65.7 |
| P14138 | Endothelin-3 | 6.24 | 25,454 | EDN3 | −55.0 |
| Q6ZMI3 | Gliomedin | 8.10 | 58,957 | GLDN | −43.0 |
| Q9UBU3 | Appetite-regulating hormone | 5.35 | 12,911 | GHRL | −37.0 |
| P61073 | C-X-C chemokine receptor type 4 | 8.46 | 39,746 | CXCR4 | −32.7 |
Protein accession number, protein description, pI (isoelectric point), the Molecular weight (Mw), gene name of that protein, and fold change (Pancreas-T2D vs Pancreas-Control) are presented for each gene in this Table. The Mw expressed in Da. pI resulted from whole amino acid sequence of each protein and is derived from www.expasy.org.