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. 2015 May 27;6(30):29833–29846. doi: 10.18632/oncotarget.4006

Figure 3. SCs upregulate the Mev pathway activity, the RhoA/RhoA kinase cascade and the HIF-1α/Pgp axis in IGHV UM but not in IGHV M CLL cells.

Figure 3

The production of cholesterol and FPP A. the amount of GTP-bound RhoA and the activity of the RhoA kinase B. the transcriptional activity of HIF-1α and the expression of the MDR1 gene C. were higher in IGHV UM cells cultured for 24 hours with M2–10B4 SCs compared to IGHV UM cells cultured alone (*p always ≤ 0.002). SCs did not have a significant impact on the activity of the Mev pathway and downstream molecules in IGHV M cells. In all panels, bars represent mean values ± SEM of side-by-side experiments performed in replicates.