Figure 1. The combination of MEK inhibitor PD0325901 with SRC inhibitor Saracatinib promoted synergistic inhibition of cell growth in NSCLC cell lines.
Cell proliferation IC50 plots (mean ± SD) for a panel of 28 NSCLC cell lines treated with PD0325901 A. Saracatinib B. or at a fixed PD0325901 to Saracatinib ratio of 0.25:1 C. for 72 h. Data were tabulated from three independent experiment sets. IC50 < 2 μM indicates cell lines are sensitive to drug (lower dotted line), IC50 > 10 μM indicates cell lines are insensitive to drug (upper dotted line). D. combination index (CI) box plots of PD0325901 and Saracatinib co-treatment at the ratio of 0.25:1 on the cell line panel. Combination index of CI < 0.8 indicates synergism, CI from 0.8 to 1.2 indicates additive effect, and CI > 1.2 indicates antagonism.