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. 2015 Aug 31;6(30):30017–30034. doi: 10.18632/oncotarget.5013

Figure 4. Drp1 is also needed in the induction of intrinsic apoptosis process.

Figure 4

A–C. SW480, HCT116 WT and HCT116 Bax−/− cells were treated with arenobufagin in the absence or presence of Drp1 siRNA (100 nM) and Mdivi-1 (50 μM). The proportion of annexin V-positive cells was analyzed by flow cytometry (n = 3). D. Confocal immunofluorescence of Bax (red, anti-Bax) in the Drp1 siRNA and Mdivi-1 SW480 cells that were loaded with MitoTracker and DAPI (n = 3). 1000× for all, scale bar = 10 μm. See also Supplementary Figure S4.