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. 2015 Aug 13;6(30):30057–30071. doi: 10.18632/oncotarget.4996

Table 1. Tyrosine kinases analyzed and available drugs that act on them.

Name Drugs
EGFR Gefitinib, Erlotinib Cetuximab, Lapatinib, Afatinib, Neratinib
HER2 Trastuzumab, Lapatinib, Pertuzumab, T-DM1, Afatinib, Neratinib
HER3 Sapitinib, MM-121, Patritumab, Canertinib
c-Kit Imatinib, Nilotinib
Met Crizotinib, Cabozantinib, Foretinib
PDGFRα Imatinib, Ponatinib Sorafenib, Pazopanib
PDGFRβ Imatinib, Sunitinib, Axitinib Sorafenib, Pazopanib
Flt3 Quizartinib, Sunitinib, Lestaurtinib
CSF-1R Lucitanib
Ret1 Cabozantinib, Vandetanib, Regorafenib, Ponatinib, Sunitinib
Ret2 Cabozantinib, Vandetanib, Regorafenib, Ponatinib, Sunitinib
IGF1R Figitumumab, Ganitumab, Cixutumumab, Dalotuzumab, Robatumumab
VGFR1 Pazopanib, Sunitinib, Vatalanib
VGFR2 Ramucirumab, Pazopanib, Sunitinib, Vandetanib, Regorafenib, Lenvatinib
VGFR3 Pazopanib, Lenvatinib, Cediranib
FAK Defactinib, GSK-2256098, PF-562,27, VS-4718
Src Dasatinib, Saracatinib, Bosutinib
Abl Imatinib, Nilotinib, Dasatinib, Ponatinib
FGFR1 Dovitinib, Lucitanib, BGJ398, AZD4547
FGFR2 Dovitinib, Lucitanib, BGJ398, AZD4547
FGFR3 Dovitinib, BGJ398, AZD4547
FGFR4 BGJ398, AZD4547