Figure 6. Effect of luteolin on tumor growth in vivo.

A. SK-Hep1 cells (1 × 10⁷) were injected subcutaneously. Vehicle or luteolin (20 mg/kg/d) was injected intraperitoneally into mice daily for 2 weeks after inoculation. Tumor size was measured in 4 mice weekly after starting the injections, and are shown as means ± SEM. B. Photographs of mice treated with vehicle or luteolin taken after sacrifice. C. Tumors were collected from the sacrificed mice, and their sizes were compared. D. Tumor weights were measured after sacrifice of mice, and are shown as means ± SEM. E. Histological differences in liver tissues from mice treated with vehicle or luteolin were compared using H&E staining. Representative photomicrographs of tumor sections taken at a magnification of 400x. Scale bar indicates 50 μm. (*p < 0.05)