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A. The 1203bp CpG site in the promoter region of RASSF8. B. TCGA data showed an inverse relationship between RASSF8 methylation and RASSF8 mRNA expression in melanoma. C. RASSF8 methylation was higher in stage III/IV advanced melanomas than in stage I/II early melanomas. D. The expression of RASSF8 in metastatic melanoma lines with low RASSF8 expression was induced by treatment with 5-aza for 72 hrs.
