Table 1. Patient clinical data, treatment history and pathology.
| Patient Characteristics | All Patients n = 159 (%) | IDHmut n = 141 (%) | Codel n = 69 (%) | ATRX loss n = 64 (%) | IDHwt n = 14 (%) |
|---|---|---|---|---|---|
| Age, in years: ≤ 40 | 98 (62) | 90 (64) | 40 (58) | 44 (69) | 4 (29) |
| >40 | 61 (38) | 51 (36) | 29 (42) | 20 (31) | 10 (71) |
| Sex: Female | 69 (43) | 59 (42) | 40 (58) | 18 (28) | 6 (43) |
| Male | 90 (57) | 82 (58) | 29 (42) | 46 (72) | 7 (50) |
| Location: Frontal onlya | 89 (56) | 85 (60) | 46 (67) | 35 (55) | 2 (14) |
| Multiple lobesb | 21 (13) | 17 (12) | 8 (12) | 9 (14) | 4 (29) |
| Insulac | 11 (7) | 8 (6) | 4 (6) | 6 (9) | 0 (0) |
| Temporal only | 17 (11) | 11 (7) | 1 (0) | 8 (12) | 7 (50) |
| Parietal/Parieto-occipital | 20 (13) | 18 (13) | 10 (15) | 7 (10) | 1 (7) |
| Brainstem | 1 (0) | 1 (0) | 0 (0) | 0 (0) | 0 (0) |
| Presented with seizure | 113 (71) | 98 (70) | 50 (73) | 43 (67) | 11 (79) |
| Surgery: >90% resected | 87 (55) | 80 (57) | 41 (59) | 31 (48) | 6 (43) |
| Subtotal | 50 (31) | 42 (30) | 16 (23) | 27 (42) | 7 (50) |
| Biopsy | 22 (14) | 19 (13) | 12 (17) | 6 (9) | 1 (7) |
| Post-op treatment: Observation | 91 (57) | 81 (57) | 43 (62) | 31 (48) | 9 (64) |
| RT alone | 54 (34) | 48 (34) | 20 (29) | 27 (42) | 4 (29) |
| RT + adjuvant chemo | 4 (3) | 3 (2) | 2 (3) | 2 (3) | 0 (0) |
| RT/TMZ + adj TMZ | 8 (5) | 7 (5) | 2 (3) | 4 (6) | 1 (7) |
| Chemo alone | 2 (1) | 2 (1) | 2 (3) | 0 (0) | 0 (0) |
| Diagnosis: Astrocytoma | 21 (13) | 13 (9) | 2 (3) | 11 (17) | 8 (57) |
| Oligodendroglioma | 49 (31) | 42 (30) | 36 (52) | 7 (11) | 4 (29) |
| Oligoastrocytoma | 89 (56) | 86 (61) | 31 (45) | 46 (72) | 2 (14) |
| p53 expression: | |||||
| 0–10% | 71 (45) | 65 (46) | 50 (72) | 12 (18) | 5 (36) |
| 11–50% | 34 (21) | 28 (20) | 12 (17) | 15 (23) | 6 (43) |
| 51–80% | 38 (24) | 35 (25) | 0 (0) | 29 (45) | 3 (21) |
| >80% | 3 (2) | 3 (2) | 0 (0) | 3 (5) | 0 (0) |
a
Frontal lobe only, excluding insula
b
Multiple lobes involved including frontal defined as frontal lobe involved plus at least one adjacent lobe excluding the insula
c
Insula with possible involvement of adjacent frontal and/or temporal lobe