Table S2.

Adjusted mean FVC AUC_0–12, AUC_0–24, and AUC_12–24 responses after 6 weeks of treatment: treatment differences (full analysis set)

	Treatment comparison
	Tiotropium + olodaterol 5/5 µg versus		Tiotropium + olodaterol 2.5/5 µg versus
	Salmeterol + fluticasone propionate 50/500 µg	Salmeterol + fluticasone propionate 50/250 µg	Salmeterol + fluticasone propionate 50/500 µg	Salmeterol + fluticasone propionate 50/250 µg
FVC AUC0–12, mL
Adjusted mean (SE)	218 (18)*	215 (18)*	183 (18)*	180 (18)*
95% CI	184, 253	180, 250	149, 218	146, 215
FVC AUC0–24, mL
Adjusted mean (SE)	176 (17)*	177 (17)*	140 (17)*	141 (17)*
95% CI	144, 209	144, 209	108, 173	108, 173
FVC AUC12–24, mL
Adjusted mean (SE)	135 (18)*	138 (18)*	98 (18)*	101 (18)*
95% CI	100, 170	103, 174	63, 133	66, 136

Notes:

^*P<0.0001. The adjusted mean (SE) was obtained from fitting a mixed-effects repeated-measures model including the following: fixed effects of treatment and period; period baseline and patient baseline as covariates; patient as a random effect; compound symmetry covariance structure for within-patient variation; and Kenward–Roger approximation of denominator degrees of freedom.

Abbreviations: AUC_0–12, area under the curve from 0 hour to 12 hours; AUC_0–24, area under the curve from 0 hour to 24 hours; AUC_12–24, area under the curve from 12 hours to 24 hours; CI, confidence interval; FVC, forced vital capacity; SE, standard error.