Table 2.

Draper–Lin small composite design formulations and the observed values of the studied responses

Run	X1 (%)	X2 (%)	X3 (rpm)	X4 (min)	Y1 observed	Y1 fit	Y2 observed	Y2 fit
1	0.65	22.5	15,000	1.59	2,280	2,319.09	19.48	14.48
2	0.3	10	10,000	5	1,977	1,954.77	25.74	30.20
3	1	10	10,000	15	2,735	2,712.77	15.94	20.40
4	1	35	10,000	5	3,955	3,932.77	13.27	17.73
5	0.65	43.52	15,000	10	3,767	3,806.09	13.45	8.45
6	0.061	22.5	15,000	10	2,356	2,395.09	18.94	13.94
7	0.3	35	20,000	15	2,076	2,042.96	20.53	23.13
8	0.65	22.5	23,409	10	1,688	1,739.94	56.87	54.08
9	0.65	22.5	15,000	18.41	2,508	2,547.09	18.54	13.54
10	1	35	20,000	5	2,827	2,793.96	16.84	19.44
11	0.65	1.478	15,000	10	745	784.088	146.41	141.41
12	0.3	10	20,000	5	934	900.956	139.86	142.46
13	0.3	35	10,000	15	2,310	2,287.77	19.85	24.311
14	1	10	20,000	15	2,357	2,323.96	18.81	21.41
15	1.24	22.5	15,000	10	2,841	2,880.09	15.67	10.67
16	0.65	22.5	6,591	10	2,902	2,928.23	13.43	6.22
17	0.65	22.5	15,000	10	2,601	2,560.71	16.11	21.89
18	0.65	22.5	15,000	10	2,612	2,560.71	15.98	21.89

Note: Each reading for Y1 and Y2 represents an average of three runs with SD <5% of the mean.

Abbreviations: X1, stabilizer concentration; X2, miscible solvent ratio; X3, homogenization speed; X4, homogenization time; Y1, particle size (nm); Y2, solubility enhancement (%); SD, standard deviation.