Figure 2.

Increased numbers of activated pDC are found following a 12-week combined exercise program in MS. Enumeration of the absolute number of circulating pDC (a) and cDC (b) was determined by means of a double platform method using an automatic cell counter and flow cytometry before start of the study (open bars) and after 12 weeks (filled bars). The activation state (c, d) and the migratory profile (e, f) of DC were assessed by enumerating pDC and cDC expressing CD80, CD86, CD62L, CCR5, and CCR7. Results are shown as mean absolute number ± SEM. ^∗ P < 0.05. cDC, conventional dendritic cells; pDC, plasmacytoid dendritic cells; EX, exercise group; SED, sedentary control group; SEM, standard error of the mean.