Table 1.
Characteristics of the NARCOMS and DER-401 cohorts
| Characteristic | NARCOMS cohort8 (n=3,505) | DER-401 study9
|
|
|---|---|---|---|
| Baseline (n=429) | Week 4 (n=398) | ||
| Age, mean (SD) | 56.7 (10.0) | 52.6 (9.5) | 52.6 (9.5) |
| Female,% | 80.7 | 69.9 | 70.4 |
| MSWS-12 score, mean (SD) | |||
| Total score | 50.8 (33.5) | 62.4 (24.2) | 53.0 (25.8) |
| Item 1 | 2.67 (1.39) | 3.12 (1.03) | 2.88 (1.07) |
| Item 2 | 3.86 (1.57) | 4.33 (1.24) | 4.18 (1.28) |
| Item 3 | 2.91 (1.44) | 3.42 (1.12) | 3.20 (1.17) |
| Item 4 | 2.68 (1.38) | 3.07 (1.09) | 2.81 (1.12) |
| Item 5 | 2.86 (1.35) | 3.36 (1.08) | 3.01 (1.10) |
| Item 6 | 3.23 (1.49) | 3.65 (1.12) | 3.23 (1.18) |
| Item 7 | 3.04 (1.46) | 3.39 (1.17) | 2.96 (1.18) |
| Item 8 | 2.63 (1.61) | 3.28 (1.39) | 2.87 (1.39) |
| Item 9 | 2.81 (1.72) | 3.38 (1.51) | 3.03 (1.46) |
| Item 10 | 3.23 (1.50) | 3.52 (1.19) | 2.95 (1.26) |
| Item 11 | 3.26 (1.49) | 3.66 (1.11) | 3.10 (1.19) |
| Item 12 | 3.29 (1.49) | 3.78 (1.20) | 3.21 (1.25) |
| EQ-5D-3L, mean (SD) | 0.74 (0.18) | 0.70 (0.17) | 0.73 (0.15) |
Abbreviations: NARCOMS, North American Research Committee on Multiple Sclerosis; DER, dalfampridine extended release; EQ-5D-3L, EuroQol 5-dimension 3-level version; MSWS-12, 12-item Multiple Sclerosis Walking Scale; SD, standard deviation.