Table 2. Correlation tests for PANSS scores and levels of olanzapine and its metabolite DMO.
| All (n = 151) | DMO | OLZ | OLZ/DMO |
|---|---|---|---|
| PANSS, total | |||
| rs = | 0.125 | -0.174* | -0.250*¶ |
| p = | 0.127 | 0.0328 | 0.00201 |
| PANSS, positive | |||
| rs = | 0.0369 | -0.152 | -0.188* |
| p = | 0.652 | 0.0623 | 0.0211 |
| PANSS, negative | |||
| rs = | 0.178* | -0.0206 | -0.148 |
| p = | 0.0285 | 0.802 | 0.0696 |
| PANSS, general | |||
| rs = | 0.0651 | -0.240*¶ | -0.244*¶ |
| p = | 0.427 | 0.00301 | 0.00256 |
| Nonsmokers (n = 111) | |||
| PANSS, total | |||
| rs = | 0.175 | -0.143 | -0.289*¶ |
| p = | 0.0658 | 0.135 | 0.00219 |
| PANSS, positive | |||
| rs = | 0.113 | -0.0861 | -0.184 |
| p = | 0.236 | 0.368 | 0.0527 |
| PANSS, negative | |||
| rs = | 0.195* | 0.012 | -0.190* |
| p = | 0.04 | 0.901 | 0.0456 |
| PANSS, general | |||
| rs = | 0.116 | -0.197* | -0.254* |
| p = | 0.227 | 0.038 | 0.00737 |
| Smokers (n = 40) | |||
| PANSS, total | |||
| rs = | -0.0434 | -0.286 | -0.162 |
| p = | 0.789 | 0.0732 | 0.315 |
| PANSS, positive | |||
| rs = | -0.251 | -0.407* | -0.202 |
| p = | 0.117 | 0.00945 | 0.209 |
| PANSS, negative | |||
| rs = | 0.127 | -0.0924 | -0.0689 |
| p = | 0.433 | 0.568 | 0.671 |
| PANSS, general | |||
| rs = | -0.103 | -0.399* | -0.239 |
| p = | 0.523 | 0.011 | 0.137 |
*p value <0.05; Spearman’s rank order correlation method.
¶rs remained significant after FDR correction.
Abbreviations: OLZ, olanzapine; DMO, N-desmethyl-olanzapine; C/D ratio, concentration-dose ratio; PANSS, Positive and Negative Syndrome Scale