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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2015 Nov 18;11(1):182–191. doi: 10.1007/s11481-015-9644-7

Fig. 3. gp120Bal decreased NR1 phosphorylation via NMDARs and AMPARs.

Fig. 3

A–C, effects of D-APV on gp120Bal-induced decrease of p-Ser896 NR1 (A), p-Ser897 NR1 (B) and total NR1 (C). Primary cortical cultures (14 DIV) were pretreated with vehicle or 100 μM D-APV for 30 min and then incubated with 200 pM gp120Bal for 12 h, followed by western blot analysis. D–F, effects of CNQX on gp120Bal-induced decrease of p-Ser896 NR1 (D), p-Ser897 NR1 (E) and total NR1 (F). Primary cortical cultures (14 DIV) were pretreated with vehicle or 50 μM CNQX for 30 min and then co-cultured with 200 pM gp120 Bal for 12 h, followed by western blot. Quantitative results in graphs are shown as mean ± SEM (*P<0.05; **P<0.01, n≥ 3, vehicle (g) is vehicle of gp120Bal; vehicle (D) is vehicle of D-APV; vehicle (C) is vehicle of CNQX).