Table 4.

Activity testing results

Activity Test	Non Transgenic mean +/− SEM	rTg4510 + IgG1 mean +/− SEM	rTg4510 + MC-1 Mean +/− SEM	rTg4510 + Tau 5 Mean +/− SEM
Open Field Distance Traveled	50.6 +/− 5.9	126 +/− 28	149 +/− 26	143 +/− 26
Rotarod – Total time	40.5 +/− 5.1	57.3 +/− 6.7	44.4 +/− 6.7	48.2 +/− 6.0
Y-Maze – Number of Entries	38.9 +/− 3.6	51.8 +/− 10.1	44.4 +/− 8.9	46.4 +/− 4.8
Y-Maze - Alternations	55.2 +/− 3.7	58.3 +/− 6.4	64.0 +/− 5.8	61.4 +/− 4.2

Our laboratory has observed that rTg4510 mice typically display much greater activity levels than NonTg mice, as mentioned above. Such activity is demonstrated here, by comparing distance traveled in the Open Field test, the time on the Rotarod and the number of entries in the Y-Maze. Slight increases are also shown in the number of alternations in the Y-Maze. Treatment of the rTg4510 mice with either MC-1 or Tau 5 did not significantly impact performance compared to IgG1 treatment.