Table 1.

Potential causes of secondary or acquired sucrase-isomaltase deficiency or maldigestion

Villous atrophy or alteration

Celiac disease

Non-tropical sprue

Chemotherapy and radiation enteropathy

Crohn’s disease

Allergic enteropathy

Immunodeficiency

Malnutrition

Infection

Acute gastroenteritis

Giardiasis

Tropical sprue

HIV enteropathy

Small intestinal bacterial overgrowth

Rapid transit

Rapid gastric emptying

Chronic nonspecific diarrhea

Dumping syndrome

Ulcerative, microscopic, and lymphocytic colitis