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. 2016 Feb 9;7:105. doi: 10.3389/fmicb.2016.00105

FIGURE 2.

FIGURE 2

Dendritic cell cryptococcal killing and antigen presentation. Immature dendritic cells efficiently phagocytose and kill opsonized Cryptococcus neoformans cells, leading to DC maturation, shown by upregulation of costimulatory molecules (MHC II, CD80, CD86) and antigen presentation to CD4+ T cells. In contrast, C. gattii can also be phagocytosed and killed by DCs, but leads to a downregulation of DC maturation and expression of costimulatory molecules MHC II, CD80, CD86 and reduces antigen presentation to T cells.