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. 2016 Feb 9;7:105. doi: 10.3389/fmicb.2016.00105

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Copyright © 2016 Leopold Wager, Hole, Wozniak and Wormley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cryptococcal Pattern Recognition Receptors. Cryptococcus has multiple pathogen associated molecular patterns (PAMPs) that are recognized by many types of pattern recognition receptors (PRRs). GXM is recognized by TLR2 and TLR4. Cryptococcal mannan can be recognized by the C-type lectin receptors Dectin-2, DC-SIGN, and CD206 or mannose receptor. B-glucans found in the cryptococcal cell wall can be recognized by Dectin-1, and cryptococcal DNA can be recognized by the endosomal receptor TLR9.