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The 3-D locations in a full-length gp120 of adaptive mutations. Adaptive amino acid substitutions are highlighted by colored globules on the gp120 models in CD4-free (A) and CD4-bound (B) states. Amino acid residues in V1/V2 and V3 regions are highlighted by red and blue colors, respectively. For details of the two models, see Figures 2A and 3A.
