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. 2016 Feb 9;9:11. doi: 10.3389/fnmol.2016.00011

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Copyright © 2016 McNally, Poplawski, Mayweather, White and Abel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of H3.3-HA in excitatory neurons of the forebrain does not affect exploration, anxiety-related behavior, or spatial memory. (A) There was no difference in total ambulation (as measured by beam breaks) between genotypes across 30 min of exploration in an open field. (B) Double-transgenic and wildtype mice exhibited a comparable preference for the periphery of an open field vs. the center (n = 9–11 per group). (C) Schematic diagram illustrating the object-location memory (OLM) task during habituation (left), training (middle) and testing (right). Testing was performed 24 h after training. Both genotypes showed a decrease in total object exploration time during the three consecutive training sessions, as expected. (D) Double-transgenic and wildtype mice exhibited a comparable and significant preference for the displaced object during testing as compared to training, signifying long-term object-location memory. Preference for the displaced object was calculated as the percentage of object exploration time dedicated to this object as compared to all objects (DO/(DO + NDO). Dotted line indicates chance performance. Data are presented as group means ± SEM (n = 18 per group). *p < 0.05.