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. 2016 Feb 9;10:11. doi: 10.3389/fnins.2016.00011

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Copyright © 2016 Prodanov and Delbeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible Motion - Reaction - Diffusion feedback loop in chronic implantation. The positive feedback loops are indicated in red. Key element in the proposed mechanism is the sustained gradient of ROS. Depicted pathways are based on the recent findings of real-time immuno-chemical expression patterns (Karumbaiah et al., 2013; Saxena et al., 2013), two-photon imaging (Rosidi et al., 2011; Kozai et al., 2012) and detailed histological characterizations (Azemi et al., 2011; Potter et al., 2013; Woolley et al., 2013).