Figure I.

Neural Gain Impairments Drive Behavioral Variability in Corticostriatal Loops. (A) Corticostriatal loop models describe how information is processed and represented in these loops. (B) Under low neural gain, differentiation of representations is poor and behavior unstable. High gain leads to clearly differentiated representations and stable behavior. Abbreviations: GPe, globus pallidus externus; GPi, globus pallidus internus; NAcc, nucleus accumbens; SNr, substantia nigra; STN, subthalamic nucleus; Str, striatum; Thal, thalamus.