Figure 1.

[Ca²⁺]_i responses induced by acetaminophen (APAP) or H₂O₂ in HepG2 cells. (A) [Ca²⁺]_i rises induced by APAP for 10 min at indicated concentrations in HepG2 cells. Average time courses (left) and maximal rise of [Ca²⁺]_i (Δ[Ca²⁺]_i) (right) (n = 23–56). (B) [Ca²⁺]_i rises induced by H₂O₂ for 10 min at indicated concentrations in HepG2 cells. Average time courses (left) and Δ [Ca²⁺]_i (right) (n = 21–45). Data points are mean ± SEM. P ≥ 0.05, ^**P < 0.01, and ^***P < 0.001 compared with control. Differences not statistically significant are labeled as (ns). All data were analyzed by Student's t-test.