Table 1.
Different roles of microRNA in γ globin expression
| microRNA | Target(mRNAorprotein) | Biologicaleffect | Reference |
|---|---|---|---|
| Lin28B | BCL11A | Increasing γ globin gene expression | (66) |
| Let-7 | γ globin mRNA | Suppressing γ globin expression | (50,67) |
| miR-15a/-16-1 | MYB mRNA | Increasing γ globin gene expression | (11,33) |
| miR-23a/27a | KLF3 and SP1 mRNAs | Regulating β-like globin gene expression | (57) |
| miR-26b | GATA1 RNA | Increasing γ globin gene expression | (64) |
| miR-96 | CDS region of γ globin mRNA | Suppressing γ globin gene expression | (50) |
| miR-126 | MYB mRNA | Decreasing MYB levels and suppressing erythropoiesis | (68) |
| miR-144 | 1. GATA1 mRNA | 1. Negatively regulating the α globin in embryonic erythropoiesis | (21,44,65,69) |
| 2. KLFD mRNA | 2. Inducing of γ globin gene transcription | ||
| 3. NRF2 mRNA | 3. Interference with antioxidant capacity; susceptibility to oxidative stress, hemolysis and severe anemia | ||
| miR-146a | γ globin | Suppressing γ globin gene expression | (50) |
| miR-150 | MYB mRNA | Suppressing α globin synthesis and erythropoiesis | (39,70) |
| miR-199-5p | c-Kit | Regulating of human erythropoiesis and decrease HbF levels | (71) |
| miR-210 | To be identified | Increasing following erythroid differentiation and indirectly increase HbF | (28,61) |
| miR-221/-222 | c-Kit | Decreasing of erythroblast proliferation and HbF levels | (58) |
| miR-451 | 1. GATA-1 and GATA-2 mRNAs | 1. Inducing γ globin gene transcription and suppress α globin, Glycophorin-A | (35,65,72,73) |
| 2. 14–3-3ζ mRNA | 2. inhibiting nuclear accumulation of FoxO3 transcription factors, a positive regulator of erythroid antioxidant genes | ||
| miR-486-3p | BCL11A | Increasing expression of γ globin gene | (14) |
miR; MicroRNAs, BCL11A; B-cell lymphoma/leukemia 11A protein, MYB; Proto-oncogene mRNA, KLF3; Krüppel-like factor 3 mRNA, SP1; Specificity protein 1 mRNA, GATA1/2; GATA-binding factor 1/2 mRNA, CDS region; Coding DNA Sequence region mRNA, KLFD; Krüppel-like factor d mRNA, NRF2; Nuclear factor (erythroid-derived 2)-like 2 mRNA, c-Kit; Tyrosine-protein kinase Kit or CD117 tyrosine-protein kinase Kit or CD117 protein and HbF; Fetal hemoglobin.