Fig. 2.

Concentration-effect relationship for inhibition of GluD2^LC currents by selected compounds. Representative current traces for D-Ser (A) and 7-CKA (B) illustrate the recording protocol used for determination of compound potency for inhibition of constitutively active GluD2^LC receptors expressed in Xenopus oocytes. (C) Average composite concentration-response curves. Error bars are the S.E.M. and are shown when larger than symbol size. The current responses are normalized to the maximal response produced by D-Ser. ACPC, 1-aminocyclopropane carboxylic acid; BMTX, 5-bromo-7-(trifluoromethyl)-1,4-dihydroquinoxaline-2,3-dione; β-flu-Ala, β-fluoro-DL-alanine; PBSA, 2-phenyl-1H-benzo[d]imidazole-5-sulfonic acid.