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7-CKA structure-activity relationship. Shown is the quinoline scaffold of 7-CKA (A) with ring positions numbered from 1 to 8 along with graphical summary (B) of the activity of analogs with various combinations of ring substituents (R1–R8). Activity measured as compound inhibition of GluD2LC current tested at a compound concentration of 0.1 or 1 mM relative to the inhibition by D-Ser at a similar concentration. Compound numbers refer to the listing in Supplemental Table S4.
