Table 3.

Relative differences in PUFA concentrations (mg/ml) by FADS genotypes compared to the reference genotype in NC1 and NC2^a,^b,^c.

SNP	Cohort	Genotype	LA	AA	LA:AA	ALA	DHA	EPA	ALA:DHA	ALA:EPA
FADS1-FADS2 rs3834458	NC1	TTd	1.000	1.000	1.000	1.000	1.000	1.000	1.000	1.000
		Tdel	1.054	0.922	1.142	1.243	1.019	1.004	1.259	1.122
		Deldel	1.041	0.835	1.253	1.213	0.934	0.982	1.282	1.359
		P-value	0.154	0.004	<0.001	0.133	0.915	0.970	0.165	0.256
	NC2	TTd	1.000	1.000	1.000	1.000	1.000	1.000	1.000	1.000
		Tdel	1.044	0.933	1.106	1.011	1.019	1.014	0.987	1.000
		Deldel	1.120	0.799	1.426	1.064	0.940	1.023	1.244	1.036
		P-value	0.002	<0.001	<0.001	0.017	0.517	0.206	0.028	0.358
FADS2 rs174575	NC1	CCd	1.000	1.000	1.000	1.000	1.000	1.000	1.000	1.000
		CG	1.019	0.982	1.055	1.153	1.081	1.046	1.106	0.914
		GG	1.075	0.858	1.260	0.931	0.949	0.979	0.941	0.961
		P-value	0.399	0.118	0.002	0.393	0.664	0.538	0.694	0.743
	NC2	CCd	1.000	1.000	1.000	1.000	1.000	1.000	1.000	1.000
		CG	1.024	0.988	1.036	1.002	1.000	1.001	1.002	1.001
		GG	0.991	0.872	1.122	0.991	0.924	0.985	1.088	1.005
		P-value	0.288	0.025	0.342	0.842	0.371	0.680	0.483	0.966

^aNC1, Nutrition Cohort 1; NC2, Nutrition Cohort 2; LA, linoleic acid; AA, arachidonic acid; ALA, α-linolenic acid; del=one base-pair deletion.

^bWe present relative difference in PUFA concentrations by genotype compared to the mean concentration in homozygote carriers of the reference genotype. Therefore values greater than one show an average increase compared to the reference SNP and values less than one show an average decrease compared to the reference SNP. Bolded P-values, derived from unadjusted ANOVA, identify groups that differ significantly by genotype.

^crs3834458 is FADS1-FADS2 intergenic (NCBI).

^dReference genotype.