. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2015 Sep 14;0:13–20. doi: 10.1016/j.plefa.2015.08.004

Table 4.

Relative differences in child developmental scores by mother’s genotype compared to the reference genotype from linear regression models^a,^b,^c.

BSID-II Outcome/SNP	Genotype	NC1 BSID-II scores				NC2 BSID-II scores
BSID-II Outcome/SNP	Genotype	n	Relative mean	95% CI	P	n	Relative mean	95% CI	P
MDI	TT^d	145	1.00	(0.982,1.018)	0.06	924	1.00	(0.992,1.008)	0.18
FADS1-FADS2 rs3834458	Tdel	61	1.02	(0.996,1.051)		343	1.01	(1.000,1.025)
	Deldel	13	1.01	(0.951,1.069)		39	1.01	(0.972,1.046)
MDI	CC^d	127	1.00	(0.981,1.019)	0.88	800	1.00	(0.992,1.008)	0.50
FADS2 rs174575	CG	75	1.01	(0.982,1.030)		437	1.01	(0.996,1.018)
	GG	11	1.01	(0.944,1.071)		68	1.01	(0.984,1.040)
PDI	TT^d	143	1.00	(0.975,1.025)	0.07	923	1.00	(0.993,1.007)	0.06
FADS1-FADS2 rs3834458	Tdel	60	1.04	(1.001,1.078)		342	1.02	(1.004,1.027)
	Deldel	13	1.04	(0.961,1.124)		39	1.02	(0.985,1.053)
PDI	CC^d	126	1.00	(0.974,1.026)	0.91	798	1.00	(0.992,1.008)	0.69
FADS2 rs174575	CG	74	1.01	(0.972,1.039)		435	1.01	(0.996,1.017)
	GG	11	1.00	(0.916,1.091)		70	1.00	(0.973,1.024)

NC1, Nutrition Cohort 1; NC2, Nutrition Cohort 2; del=one base-pair deletion; BSID-II, Bayley Scales of Infant Development II; MDI, Mental Developmental Index; PDI, psychomotor developmental index.

β Coefficients, 95% CI and P values presented are from linear regression models adjusted for child sex, maternal age at delivery, presence of two parents in the household, socioeconomic status, and birth weight (for NC1) or child age at testing (NC2). P-values are from the 2 df tests comparing the 3 levels of each genotype.

rs3834458 is FADS1-FADS2 intergenic (NCBI).

Reference genotype.