Table 2. Associations between cerebrovascular disease, Aβ isoforms and amyloid PET per diagnostic group.
| Group | Parameter | WML volume ± 95% CI | Fazekas score ± 95% CI | Lacunes ± 95% CI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cognitively | CSF Aβ38 | −0.151** | −0.260 | −0.042 | −0.071 | −0.191 | 0.048 | −0.254 | −1.369 | 0.861 |
| healthy | CSF Aβ40 | −0.118* | −0.228 | −0.008 | −0.058 | −0.178 | 0.061 | −0.363 | −1.940 | 1.213 |
| elderly | CSF Aβ42 | −0.075 | −0.185 | 0.036 | 0.017 | −0.103 | 0.137 | −0.795 | −2.406 | 0.815 |
| Composite SUVR | 0.037 | −0.137 | 0.210 | −0.057 | −0.241 | 0.127 | 0.570 | −2.911 | 4.052 | |
| Subjective | CSF Aβ38 | −0.211** | −0.341 | −0.081 | −0.170* | −0.312 | −0.028 | 2.306 | −0.317 | −0.030 |
| cognitive | CSF Aβ40 | −0.243*** | −0.371 | −0.115 | −0.197** | −0.337 | −0.057 | 1.144 | −0.309 | −0.020 |
| deficit | CSF Aβ42 | −0.079 | −0.213 | 0.055 | −0.066 | −0.211 | 0.079 | 0.976 | −0.154 | 0.142 |
| Composite SUVR | 0.099 | −0.075 | 0.273 | 0.070 | −0.118 | 0.257 | −0.686 | −0.187 | 0.231 | |
| Mild | CSF Aβ38 | −0.264*** | −0.396 | −0.133 | −0.174* | −0.317 | −0.030 | −1.947* | −3.655 | −0.239 |
| cognitive | CSF Aβ40 | −0.286*** | −0.417 | −0.155 | −0.164* | −0.309 | −0.020 | −1.018 | −2.312 | 0.276 |
| impairment | CSF Aβ42 | 0.000 | −0.138 | 0.138 | −0.006 | −0.154 | 0.142 | 0.715 | −0.501 | 1.931 |
| Composite SUVR | −0.028 | −0.226 | 0.170 | 0.022 | −0.187 | 0.231 | 0.149 | −2.755 | 3.052 | |
| PD−patients | CSF Aβ38 | −0.181** | −0.310 | −0.053 | −0.188* | −0.365 | −0.011 | NA | ||
| CSF Aβ40 | −0.185** | −0.314 | −0.056 | −0.175 | −0.225 | −0.125 | NA | |||
| CSF Aβ42 | −0.066 | −0.204 | 0.072 | 0.010 | 0.386 | −0.366 | NA | |||
| AD−patients | CSF Aβ38 | NA | −0.258* | −0.447 | −0.070 | NA | ||||
| CSF Aβ40 | NA | −0.299** | −0.485 | −0.113 | NA | |||||
| CSF Aβ42 | NA | −0.225* | −0.413 | −0.038 | NA | |||||
Values represent standardized beta (linear regression, WML volume and total Fazekas score) and Beta (logistic regression, lacunes) with 95% confidence intervals; prior to analysis, the natural logarithm of parameters was calculated where appropriate in order to ensure normal distribution. Values are corrected for age, gender and hippocampal volume; the latter was determined using Adaboost, the mean value of the left and right hippocampus was normalized using the scaling factor provided by this software to account for head size differences.
In the PD and AD groups, 2.3% and 3.6% of the subjects had lacunes and the association between CSF Aβ species and lacunes was not analyzed. Data on WML volume were not available for the AD group, where imaging mainly was performed using CT.
*p < 0.05, **p < 0.0125, ***p > 0.001.
Only p−values < 0.0125 should be considered significant according to Bonferroni−adjustment.