Table 4. Associations between regional cerebrovascular disease, Aβ isoforms and amyloid PET, pooled data from the CHE, SCD and MCI groups.

Group	Parameter	ARWMC total	ARWMC frontal	ARWMC parieto- occipital	ARWMC temporal	ARWMC infratententorial
CHE, SCD, MCI	CSF Aβ38	−0.142***	−0.130***	−0.142***	−0.155***	−0.013
	CSF Aβ40	−0.121**	−0.111**	−0.122**	−0.137**	0.019
	CSF Aβ42	−0.040	−0.026	−0.073	−0.088*	0.031
	Composite SUVR	0.094	0.088	0.084	0.136*	0.015

SVD was estimated as the total and regional white matter lesion score according to the ARWMC scale. Values represent standardized beta (linear regression, ARWMC score) with 95% confidence intervals; prior to analysis, the natural logarithm of the CSF and PET parameters was calculated to ensure normal distribution. Values are corrected for age, sex and hippocampal volume; the latter was determined using Adaboost, the mean value of the left and right hippocampus was normalized using the scaling factor provided by this software to account for head size differences. *p < 0.05, **p < 0.0125, ***p > 0.001.

Only p-values < 0.0125 should be considered significant according to Bonferroni-adjustment.