Table 3. The differences of clinical features between the DP and GCB* or non-GCB group.
| Variables | Double positive no. (%) | Vs. GCB* no. (%) | Pvalue | Vs. non-GCB no. (%) | Pvalue |
|---|---|---|---|---|---|
| Age | 80 | 152 | 369 | ||
| >60y | 36 (45) | 48 (31.6) | 0.0432 | 175 (47.4) | 0.6935 |
| ≤60y | 44 (55) | 104 (68.4) | 194 (52.6) | ||
| Sex | 80 | 152 | 369 | ||
| Male | 42 (52.5) | 89 (58.6) | 0.3768 | 214 (58.0) | 0.3681 |
| Female | 38 (47.5) | 63 (41.4) | 155 (42.0) | ||
| LDH | 79 | 152 | 369 | ||
| Over ULN | 30 (38.0) | 54 (35.5) | 0.7136 | 218 (59.1) | 0.0006 |
| Normal | 49 (62.0) | 98 (64.5) | 151 (40.9) | ||
| Stage | 79 | 152 | 369 | ||
| I/II | 39 (49.4) | 77 (50.7) | 0.8523 | 110 (29.8) | 0.0008 |
| III/IV | 40 (50.6) | 75 (49.3) | 259 (70.2) | ||
| ECOG PS | 78 | 151 | 368 | ||
| 0–1 | 66 (84.6) | 142 (94.0) | 0.0192 | 276 (75.0) | 0.0681 |
| 2–4 | 12 (15.4) | 9 (6.0) | 92 (25.0) | ||
| ESI | 79 | 152 | 369 | ||
| 0–1 | 62 (78.5) | 124 (81.6) | 0.5728 | 274 (74.3) | 0.4311 |
| >1 | 17 (21.5) | 28 (18.4) | 95 (25.7) | ||
| IPI | 78 | 151 | 368 | ||
| 0–2 | 59 (75.6) | 120 (79.5) | 0.5062 | 219 (59.5) | 0.0076 |
| >2 | 19 (24.4) | 31 (20.5) | 149 (40.5) | ||
| B symptom | 78 | 151 | 368 | ||
| Positive | 18 (23.1) | 38 (25.2) | 0.7275 | 162 (44.0) | 0.0006 |
| Negative | 60 (76.9) | 113 (74.8) | 206 (56.0) | ||
| Myc expression | 29 | 70 | 148 | ||
| Positive | 9 (31.0) | 23 (32.9) | 0.860 | 59 (39.9) | 0.371 |
| Negative | 20 (69.0) | 47 (67.1) | 89 (60.1) | ||
| Bcl2 expression | 29 | 70 | 148 | ||
| Positive | 12 (41.4) | 29 (41.4) | 0.996 | 90 (60.8) | 0.053 |
| Negative | 17 (58.6) | 41 (58.6) | 58 (39.2) | ||
| DEL | 4 (13.8) | 14 (20.0) | 0.466 | 48 (32.4.) | 0.044 |
| Non-DEL | 25 (86.2) | 56 (80.0) | 100 (67.6) | ||
| MYC-R | 28 | 70 | 148 | ||
| Positive | 7 (25.0) | 14 (20.0) | 0.586 | 12 (8.1) | 0.016 |
| Negative | 21 (75.0) | 56 (80.0) | 136 (91.9) | ||
| BCL2-R | 28 | 70 | 148 | ||
| Positive | 1 (3.6) | 14 (20.0) | 0.060 | 15 (10.1) | 0.474 |
| Negative | 27 (96.4) | 56 (80.0) | 133 (89.9) | ||
| DHL | 3 (10.7) | 2 (2.9) | 0.139 | 2 (1.4) | 0.029 |
| Non-DHL | 25 (89.3) | 68 (97.1) | 146 (98.6) |
Abbreviations: GCB: germinal center B-cell; DP: double positive (CD10+MUM1+); LDH: serum lactate dehydrogenase; ULN: upper limit of normal; ECOG PS: Eastern Cooperative Oncology Group performance status; ESI: extranodal sites involvement; IPI: International prognostic index; DEL: double expression lymphoma; R: rearrangement; DHL: double hit lymphoma.