Table 4. The differences of clinical characteristics between the TN and non-GCB* or GCB group.
| Variables | Triple negative no. (%) | Vs. non-GCB* no. (%) | Pvalue | Vs. GCB no. (%) | Pvalue |
|---|---|---|---|---|---|
| Age | 53 | 316 | 232 | ||
| >60y | 23 (43.4) | 153 (48.4) | 0.4982 | 84 (36.2) | 0.3295 |
| ≤60y | 30 (56.6) | 163 (51.6) | 148 (63.8) | ||
| Sex | 53 | 316 | 232 | ||
| Male | 29 (54.7) | 185 (58.5) | 0.6014 | 131 (56.5) | 0.8170 |
| Female | 24 (45.3) | 131 (41.5) | 101 (43.5) | ||
| LDH | 53 | 316 | 231 | ||
| Over ULN | 25 (47.2) | 193 (61.1) | 0.0567 | 84 (36.4) | 0.1446 |
| Normal | 28 (52.8) | 123 (38.9) | 147 (63.6) | ||
| Stage | 53 | 316 | 231 | ||
| I/II | 22 (44.0) | 88 (27.8) | 0.0442 | 116 (50.2) | 0.2527 |
| III/IV | 31 (56.0) | 228 (72.2) | 115 (49.8) | ||
| ECOG PS | 53 | 315 | 229 | ||
| 0–1 | 46 (86.8) | 230 (73.0) | 0.0321 | 208 (90.8) | 0.3758 |
| 2–4 | 7 (13.2) | 85 (27.0) | 21 (9.2) | ||
| ESI | 53 | 316 | 231 | ||
| 0–1 | 43(81.1) | 231 (73.1) | 0.2159 | 186 (80.5) | 0.9189 |
| >1 | 10(18.9) | 85 (26.9) | 45 (19.5) | ||
| IPI | 53 | 315 | 229 | ||
| 0–2 | 41 (77.4) | 178 (56.5) | 0.0042 | 179 (78.2) | 0.8982 |
| >2 | 12 (22.6) | 137 (43.5) | 50 (21.8) | ||
| B symptom | 53 | 315 | 229 | ||
| Positive | 17 (32.1) | 145 (46.0) | 0.0582 | 56 (24.5) | 0.2537 |
| Negative | 36 (67.9) | 170 (54.0) | 173 (75.5) | ||
| Myc expression | 21 | 127 | 99 | ||
| Positive | 3 (14.3) | 56 (44.1) | 0.010 | 30 (30.3) | 0.123 |
| Negative | 18 (85.7) | 71 (55.9) | 67 (69.7) | ||
| Bcl2 expression | 21 | 127 | 99 | ||
| Positive | 13 (61.9) | 87 (68.5) | 0.887 | 41 (41.4) | 0.086 |
| Negative | 8 (38.1) | 40 (31.5) | 58 (58.9) | ||
| DEL | 3 (14.3) | 45 (35.4) | 0.055 | 18 (18.4) | 1.000 |
| Non-DEL | 18 (85.7) | 82 (65.6) | 81 (81.6) | ||
| MYC-R | 21 | 127 | 98 | ||
| Positive | 2 (9.5) | 10 (7.9) | 0.680 | 21 (21.4) | 0.360 |
| Negative | 19 (90.5) | 117 (92.1) | 77 (78.6) | ||
| BCL2-R | 21 | 127 | 98 | ||
| Positive | 5 (23.8) | 10 (7.9) | 0.041 | 15 (15.3) | 0.345 |
| Negative | 16 (76.2) | 117 (92.1) | 83 (84.7) | ||
| DHL | 1 (4.8) | 1 (0.8) | 0.256 | 5 (5.1) | 1.000 |
| Non-DHL | 20 (95.2) | 126 (99.2) | 93 (94.9) |
Abbreviations: GCB: germinal center B-cell; TN: triple negative (CD10−Bcl6−MUM1−); LDH: serum lactate dehydrogenase; ULN: upper limit of normal; ECOG PS: Eastern Cooperative Oncology Group performance status; ESI: extranodal sites involvement; IPI: International prognostic index; DEL: double expression lymphoma; R: rearrangement; DHL: double hit lymphoma.