Table 1. General Characteristics of the Included Studies.
| First author | Year | Location | Race | Mean/median age (range) (y) | Gender (M/F) | Case (n) |
Control (n) |
Method | Control style | Control source | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M+ | U | M+ | U | |||||||||
| Hogg34 | 2002 | UK | Caucasians | NA | NA | 4 | 24 | 0 | 24 | BSP | A | NMT |
| Dong26 | 2003 | USA | Caucasians | NA | NA | 7 | 46 | 0 | 46 | MSP | A | ANT |
| Maruya22 | 2004 | USA | Caucasians | 58 (31–81) | 26/6 | 0 | 32 | 1 | 32 | MSP | A | NMT |
| Xu23 | 2006 | China | Asians | 60 (41–76) | 35/13 | 34 | 48 | 11 | 48 | MSP | A | ANT |
| Righini27 | 2007 | French | Caucasians | 57 (33–74) | NA | 14 | 90 | 0 | 30 | MSP | A | NMT |
| Wan31 | 2007 | China | Asians | NA | 17/15 | 13 | 32 | 4 | 28 | MSP | H | OCT |
| 0 | 10 | MSP | H | OCT | ||||||||
| Ghosh33 | 2008 | India | Asians | NA | NA | 23 | 111 | 9 | 52 | MSRA | H | DLT |
| Steinmann28 | 2009 | Germany | Caucasians | 57 (41–77) | NA | 10 | 54 | 0 | 23 | MSP | A | CMT |
| Su24 | 2010 | Taiwan | Asians | 55 (37–82) | 47/5 | 9 | 31 | 12 | 31 | Q-MSP | A | ANT |
| 0 | 12 | Q-MSP | H | NMT | ||||||||
| Laytragoon-Lewin29 | 2010 | Sweden | Caucasians | 62 (42–101) | 30/11 | 8 | 18 | 4 | 18 | MSP | A | NMT |
| Paluszczak30 | 2011 | Poland | Caucasians | 58 (41–75) | 35/6 | 13 | 41 | 9 | 41 | MSP | A | NMT |
| Koutsimpelas31 | 2012 | Germany | Caucasians | 62 (45–83) | 19/4 | 3 | 23 | 0 | 3 | MSP | H | GT |
Abbreviation: NA, not available; M, male; F, female; M+, methylated; U, unmethylated; A, Autologous (the control from the HNSCC patients themselves); H, Heterogeneous (the control from other individuals); NMT, normal mucosa tissue; ANT, adjacent non-tumor tissue; OCT, oral cavity tissue; DLT, dysplastic lesions tissue; CMT, cheek mucosa tissue; GT, gingiva tissue.