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. 2016 Jan 22;26(2):217–228. doi: 10.1038/cr.2016.13

Figure 4.

Figure 4

miR159 inhibits cell proliferation through targeting TCF7. (A, C) Cell counting of MDA-MB-231 cells co-transfected with miR159 and TCF7HA (A) or MYC (C). Cells were counted 4 days post-seeding. (B) Dual-luciferase assay for TCF reporter activity. MDA-MB-231 cells were co-transfected with miR159, TCF7HA and either TOPFLASH or FOPFLASH plasmids. (D) Dual-luciferase assay for E-box reporter activity. MDA-MB-231 cells were co-transfected with miR159, MYC and either E-box reporter or vector plasmids. In B and D, the luciferase assay was performed 3 days after transfection. (E) Working Model for miR159 inhibition of breast cancer growth. Data shown represent mean ± SD (n = 3). *P < 0.05.