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. 2016 Feb 9;6:20630. doi: 10.1038/srep20630

Figure 1. SNX10 deficiency ameliorates DSS-induced colitis in mice.

Figure 1

SNX10-deficient mice (KO) and littermate wild type mice (WT) were fed with 3% DSS for 7 days. (A) Weight loss was measured daily and expressed as the average percentage of initial body weight ± SEM. (B) Blood contents in stools of WT and SNX10 KO were scored on the 7th day. (C) The length of colons from WT or SNX10 KO mice was measured at day 7 after euthanasia. (D) Representative histological images (×20) and the scores of colonic inflammation of SNX10 KO and WT mice on the 7th day were compared. (E) The concentration of TNF-α, IL-12/23p40, IL-6 and IL-10 in the serum of WT and SNX10 KO mice with or without DSS induction were measured by ELISA. **P < 0.01, ***P < 0.001 vs WT normal control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs WT with DSS induction group; n = 10 in each group.