Figure 5. SNX10^−/−BMDMs protect WT mice from DSS-induced colitis.

Macrophages in WT and SNX10 KO mice were depleted by clodronate-liposomes (Clo) and then reconstituted with SNX10^−/− or WT BMDMs (KOM_ϕ, WTM_ϕ), respectively. PBS-liposomes (PBS) were used as the control. (A) Body weight changes of WT and SNX10^−/− mice in each group on day 6 and day 7 after DSS-induction. (B) Fecal occult blood of WT and SNX10 KO mice in each group at day 7 after DSS-induction was scored. (C) Representative images of colon. The length of colon in the indicated groups was statistically compared. (D) Representative H&E- stained sections of colon and histological assessment (original magnification, ×20). (E) Expression of pro-inflammatory cytokine mRNA in colonic tissues. Data are means ±SEM (n = 6 in each group). *P < 0.05, **P < 0.01 and ***P < 0.001.