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. 2016 Feb 9;6:20587. doi: 10.1038/srep20587

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Copyright © 2016, Macmillan Publishers Limited

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(A) Recombinant human POSTN increased the proliferation of HN13 and Rca-T in a dose-dependent manner, while neutralization of POSTN (100 ng/mL) with anti-POSTN (50 ng/mL) antibody inhibited the proliferation of HN13 and Rca-T. (B,C) Recombinant human POSTN (100 ng/mL) promoted the migration and invasion of HNC cells (HN13 and Rca-T), while neutralization of POSTN inhibited the migration and invasion of HNC cells (HN13 and Rca-T). (D,E) POSTN knockdown in CAFs partially inhibited the growth of HN13 and Rca-T, while POSTN overexpression in NFs facilitated proliferation of HN13 and Rca-T. (F,G) POSTN knockdown in CAFs inhibited the migratory and invasive abilities of HN13 and Rca-T; POSTN overexpression in NFs increased the migration and invasion of HN13 and Rca-T cells. (*p < 0.05; **p < 0.01; ***p < 0.001).