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. 2016 Feb 9;6:20780. doi: 10.1038/srep20780

Figure 4. NADPHd activity and genotype in individual muscle fibres.

Figure 4

Quantification of NADPHd staining show increased sarcolemmal activity in both types I and II abnormal fibres, regardless of the kind of mutation (A). Sarcoplasmic NADPHd activity is also significant increased in patients with MT-TL1 mutations but decreased in those with mtDNA deletions (B). A similar pattern is shown when we analyze SDH (C) and COX (D) staining in the same groups of fibres classified according to the genotype. SDH activity is increased in fibres with mtDNA deletions and MT-TL1 mutations. COX activity is increased in MT-TL1 mutations but reduced in mtDNA deletions. Total numbers of myofibres analysed: deletions (type I: n = 484; type II; n = 392); MT-TL1 (type I: n = 141; type II: n = 72); MT-Q (type I: n = 9; type II: n = 6) and normal (type I: n = 418; type II: n = 332). Data were analyzed by Kruskal-Wallis test followed by Dunn’s post hoc test. ****P ≤ 0.0001; *P ≤ 0.05. Bars are showing median and interquartile range.