Table 1.
Distribution of the IC50 of pyronaridine and chloroquine and the K76T mutation according to the three components defined by the Bayesian mixture modeling approach
| Component A | Component B | Component C | P-value | |
|---|---|---|---|---|
| No of isolates | 177 | 89 | 30 | |
| Pyronaridine median IC50 | 15.9 nM | 34.2 nM | 63.3 nM | <0.001 |
| Pyronaridine 25 % percentile | 11.2 nM | 30.4 nM | 51.2 nM | |
| Pyronaridine 75 % percentile | 18.5 nM | 37.1 nM | 69.7 nM | |
| Chloroquine median IC50 | 57.0 nM | 90.6 nM | 240.5 nM | 0.003 |
| Chloroquine 25 % percentile | 18.3 nM | 19.7 nM | 71.2 nM | |
| Chloroquine 75 % percentile | 207 nM | 273 nM | 301 nM | |
| No of K76T mutation (%) | 82 (46.3) | 42 (47.2) | 22 (73.3) | 0.021 |