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. 2016 Feb 9;10:15. doi: 10.1186/s12918-016-0263-6

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© Tian et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Model results suggest that IGF2R can suppress phosphorylation of IGF1R for specific quantitative combinations. a Model analysis demonstrated that IGF2R would need to be 100 times more abundant than IGF1R in order to inhibit pIGF1R by 11.2 % in OVCAR5. b Increasing IGF2 treatment doses increased the magnitude of IGF2R:IGF1R ratio required for 50 % inhibition of pIGF1R