Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Feb 8;16:71. doi: 10.1186/s12885-016-2104-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Eide et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — The MYCN, HMGA2, CDKN2A pathway. MYCN functions as a positive regulator of LIN28B, a known repressor of the let-7 family of microRNAs via binding to DICER1. Loss of let-7 microRNAs can lead to HMGA2 overexpression that may result in a downregulation of CDKN2A