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. 2016 Feb 9;16:58. doi: 10.1186/s12906-016-1036-x

Fig. 6.

Fig. 6

Schematic diagram showing the proposed apoptotic signaling pathways triggered by PP7 in HepG2 cells. PP7 treatment leads to the activation of MAPK (JNK, ERK, and p38) and PTEN/p53 signaling pathways, followed by upregulation of pro-apoptotic proteins and downregulation of anti-apoptotic protein, and eventually causes apoptosis in HepG2 cells