Table 1.
Cytotoxicity of Polyphyllin VII (PP7) against human liver cancer cells (HepG2, Hep3B, Bel7402 and 7721). Cells were treated with increasing concentrations of PP7 for 24, 48 and 72 h and cell viability was determined by MTT assay as described in Methods section. Each IC50 value represents means ± SD of 3 to 5 independent experiments
| Cell line | IC50 (μM) | ||
|---|---|---|---|
| 24 h | 48 h | 72 h | |
| HepG2 | 1.32 ± 0.04 | 0.85 ± 0.03 | 0.78 ± 0.04 |
| Hep3B | 2.61 ± 0.08 | 1.84 ± 0.06 | 1.23 ± 0.05 |
| Bel7402 | 2.86 ± 0.15 | 1.74 ± 0.06 | 1.12 ± 0.04 |
| 7721 | 2.30 ± 0.09 | 1.73 ± 0.05 | 1.28 ± 0.05 |