Table 3.
Several GO process terms were enriched within genes with hypermethylated a-CpGs in the analysis with GOrilla [21, 43]. This table represents the main clusters of processes (53 redundant GO terms were filtered out of 73 terms using REViGO [44]). The full list of processes is shown in Additional file 2: Table S2
| GO term | Description of the process | p-value (-log10) |
|---|---|---|
| GO:0048856 | Anatomical structure development | 10.9914 |
| GO:0050794 | Regulation of cellular process | 8.9788 |
| GO:0007389 | Pattern specification process | 8.2343 |
| GO:0032502 | Developmental process | 8.2041 |
| GO:0009893 | Positive regulation of metabolic process | 8.0511 |
| GO:0044708 | Single-organism behavior | 7.5544 |
| GO:0035108 | Limb morphogenesis | 7.5544 |
| GO:0003002 | Regionalization | 7.3585 |
| GO:0051239 | Regulation of multicellular organismal process | 7.301 |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | 7.2248 |
| GO:0065007 | Biological regulation | 7.1675 |
| GO:0007610 | Behavior | 7.08 |
| GO:0048598 | Embryonic morphogenesis | 7.0778 |
| GO:0048518 | Positive regulation of biological process | 6.8761 |
| GO:0048519 | Negative regulation of biological process | 6.7122 |
| GO:0008285 | Negative regulation of cell proliferation | 6.4921 |
| GO:0048523 | Negative regulation of cellular process | 5.8827 |
| GO:0010842 | Retina layer formation | 5.8041 |
| GO:0051961 | Negative regulation of nervous system development | 5.7423 |
| GO:0032774 | RNA biosynthetic process | 5.4225 |