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. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z

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© Hennig et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Model of Ras deactivation mediated by the feedback-dependent activation of neurofibromin. a Schematic cartoon of the mechanism of Ras activation/deactivation. The scheme depicts the previously reported Erk and/or Rsk-dependent feedback inhibition of GEF (Sos) activation and the feedback stimulation of neurofibromin reported herein. The dotted line linking Erk to neurofbromin symbolizes the presumptive Rsk-independent feedback loop emanating from Erk. See text for details. b Minimal mathematical model describing Ras activation/deactivation mediated by a positive feedback stimulation of Ras-GAP. R-GEF: receptor-GEF complex. See experimental section for details