Table 2.

Postoperative behavioral scores (mean ± 1 SD; n = 7) in mice treated with Bup-HCl or Bup-SR in the absence of surgery

	Time (h) after treatment	Treatment group
		Bup-HCl	Bup-SR
General activity	0	1.4 ± 0.5	1.4 ± 0.8
	1	1.4 ± 0.5	1.4 ± 0.5
	3	1.6 ± 0.5	1.6 ± 0.5
	6	1.0 ± 0.8	1.0 ± 0.8
	12	0.8 ± 0.9	1.7 ± 0.8a
	24	1.3 ± 0.9b	0.7 ± 0.8
	48	0.7 ± 0.8	0.9 ± 0.7
	72	1.1 ± 0.7	1.0 ± 0.8
Wheel running	0	18.7 ± 9.9	18.0 ± 9.9
	1	3.6 ± 5.5b	3.8 ± 5.1b
	3	8.1 ± 10.4b	3.2 ± 10.7b
	6	4.3 ± 12.2b	0.8 ± 1.3b
	12	4.3 ± 4.9b	1.0 ± 1.3b
	24	18.2 ± 13.3	9.8 ± 8.6b
	48	13.1 ± 7.4	11.5 ± 7.8
	72	14.6 ± 8.8	12.5 ± 7.4
Rearing	0	7.4 ± 9.2	9.5 ± 7.6
	1	5.0 ± 8.5	8.9 ± 8.3
	3	6.1 ± 6.6	3.0 ± 6.2
	6	4.3 ± 7.3	2.6 ± 3.4b
	12	4.4 ± 7.1	9.6 ± 8.3
	24	4.0 ± 5.7	2.0 ± 4.4b
	48	1.3 ± 1.9b	2.1 ± 2.9b
	72	2.3 ± 3.1	1.9 ± 2.4b
Grooming	0	2 ± 1.6	1.3 ± 0.9
	1	1.4 ± 1.5	1.1 ± 1.1
	3	1.9 ± 1.7	1.3 ± 1.4
	6	1.7 ± 2.1	0.6 ± 0.8
	12	1.7 ± 2.1	0.6 ± 0.8
	24	0.6 ± 1.5b	1.7 ± 1.4a
	48	2.1 ± 2.7	1.0 ± 0.8
	72	1.8 ± 2.5	1.3 ± 1.6
Wound licking	0	0 ± 0	0 ± 0
	1	0 ± 0	0 ± 0
	3	0 ± 0	0 ± 0
	6	0 ± 0	0 ± 0
	12	0 ± 0	0 ± 0
	24	0 ± 0	0 ± 0
	48	0 ± 0	0 ± 0
	72	0 ± 0	0 ± 0
Orbital tightening	0	0 ± 0	0 ± 0
	1	0 ± 0	0 ± 0
	3	0 ± 0	0 ± 0
	6	0 ± 0	0 ± 0
	12	0 ± 0	0 ± 0
	24	0 ± 0	0 ± 0
	48	0 ± 0	0 ± 0
	72	0 ± 0	0 ± 0
Percentage (%) of integrated nesting material	0	NA	NA
	1	39.3 ± 33.7	27.9 ± 11.3
	3	58.6 ± 40.2	32.1 ± 36.9a
	6	62.3 ± 36.9	81.5 ± 32.9
	12	85.0 ± 30.1	75.0 ± 25.0
	24	100.0 ± 0.0	96.4 ± 9.4
	48	100.0 ± 0.0	100.0 ± 0.0
	72	100.0 ± 0.0	100.0 ± 0.0

NA, not applicable

^aValue significantly (P < 0.05) different from that for the Bup-HCl group.

^bValue significantly (P < 0.05) different from the baseline value.