Table 2.
Preoperative Patient Characteristics and Pathologic Diagnoses
| Preteam (n = 113) |
Postteam (n = 101) |
|
|---|---|---|
| Age (years)a | 50.7 ± 1.4 | 52.4 ± 1.4 |
| Sex: # Female (% Female) | 58 (51%) | 49 (49%) |
| Lesion maximal diameter (cm) | 2.1 ± 0.1 | 2.0 ± 0.1 |
| Micro/macro (#) | 15/98 | 13/88 |
| Prior pituitary surgery | 16 | 13 |
| Hypopituitarism (%)b | 37% | 40% |
| Surgical Resection (# GTR/# PR) | 106/7 | 89/12 |
| Pathologic diagnosis | ||
| Pituitary adenoma | ||
| Nonfunctioning | 57 (50%) | 61 (61%) |
| GH | 15 (13%) | 12 (12%) |
| ACTH | 11 (10%) | 11 (11%) |
| Prolactin | 10 (9%) | 9 (9%) |
| TSH | 4 (4%) | 1 (1%) |
| Gonadotropin | 2 (2%) | 0 (0%) |
| Cysts | ||
| Rathke cleft cyst | 7 (7%) | 3 (3%) |
| Arachnoid cyst | 1 (1%) | 1 (1%) |
| Craniopharyngioma | 1 (1%) | 1 (1%) |
| Pituitary cyst | 1 (1%) | 0 (0%) |
| Other lesions | ||
| Chronic inflammatory lesion | 1 (1%) | 0 (1%) |
| Metastatic squamous cell | 0 (0%) | 1 (1%) |
| carcinoma | 1 (1%) | 0 (0%) |
| Lymphoma | 1 (1%) | 0 (0%) |
| Metastatic neuroendocrine tumor | 1(1%) | 0 (0%) |
Abbreviations: ACTH = adrenocorticotrophic hormone; GH = growth hormone; GTR = gross total resection; TS-transsphenoidal surgery, macromicroadenoma; TS = transsphenoidal surgery.
Data are presented as mean ± SD. No categories were significantly different between the groups.
Hypopituitarism was defined as deficiency of 1 or more axis based on these criteria: free thyroxine below the lower limit of normal, morning cortisol <10 µg/dL, and/or peak cortisol <18 µg/dL after Cortrosyn® stimulation testing, total testosterone below the lower limit of normal in men or amenorrhea in premenopausal women, GH deficiency based on standardized criteria (8, 31). Diabetes insipidus was considered separately and not part of the diagnosis of hypopituitarism.